Four on the Floor is inspired by boogie-woogie. It is a celebration of American music and American musicians. The metronome indication for Four on the Floor is 138-144 to the quarter note, a speed verging on breakneck, and breakneck is the theme of the piece an America that is speeding up faster and faster, jazzing into eternity.

After a short three-bar introduction, the boogie beat is laid down by the piano. Its characteristic use of triplets and a "walking bass" in the left hand continues throughout the piece. A jazzy pizzicato phrase for the three string instruments leads into a slightly slower section which features dialogue between the strings (playing in rhythmic unison) and the piano. A restatement of the earlier material is combined with a "ripping" riff.

Breathless solos for each instrumentalist bring Four on the Floor to a boisterous conclusion.